Article

Glycan Reachability Analysis: A Bottleneck-Aware Framework for Inferring Tissue-Specific Glycan Biosynthetic Potential from Transcriptomics

2026-03-27

Abstract excerpt

Glycan biosynthesis requires the coordinated expression of glycosyltransferases, modifying enzymes, and nucleotide-sugar synthesis and transport machinery. Existing computational tools predict glycan structures from gene expression using binary thresholds, losing quantitative information about relative biosynthetic capacity across tissues. Here we present glycan biosynthetic reachability analysis, which integrates...

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Literature Corpus work: e662a8cb-4097-5fbc-8def-572f945bebfa
DOI: 10.64898/2026.03.24.714093

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