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Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis

2021-09-25

Abstract excerpt

SARS-CoV-2 is a worldwide health concern, and new treatment strategies are needed 1 . Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain elusive. Here, we show that human caspase-4 (CASP4), and its mouse homologue, caspase-11 (CASP11), are upregulated in SARS-CoV-2 infections, and that CASP4 expression correlates with severity of SARS-CoV-2 infection...

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Identifiers and source

Literature Corpus work
485809f5-a415-5a45-a13b-2342236582dd
DOI
10.1101/2021.09.24.461743
Open publication

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Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosisDOI 10.1101/2021.09.24.461743
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