Article

SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release

2021-08-11

Abstract excerpt

<title>Abstract</title> <p>SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and death in a minority of patients. Although severe COVID-19 disease is linked to exuberant inflammation, how SARS-CoV-2 triggers inflammation is not understood. Monocytes and macrophages are sentinel immune cells in the blood and tissue, respectively, that sense invasive infection to form inflammasome...

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Literature Corpus work: ee440ea0-853e-50fc-af27-c76791bef5d5
DOI: 10.21203/rs.3.rs-153628/v1

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