Article

Caspase-4 dimerisation and D289 auto-processing elicits an interleukin-1β converting enzyme

2023-01-06

Abstract excerpt

The non-canonical inflammasome is a signalling complex critical for cell defence against cytosolic Gram-negative bacteria. A key step in the human non-canonical inflammasome pathway involves unleashing the proteolytic activity of caspase-4 within this complex. Caspase-4 induces inflammatory responses by cleaving gasdermin-D (GSDMD) to initiate pyroptosis, although the molecular mechanisms that activate caspase-4 a...

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Literature Corpus work: 062995d4-550f-5589-a699-64ea93e6580c
DOI: 10.1101/2023.01.05.522955

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