Article

Design of a Small Molecule That Stimulates VEGFA Informed from an Expanded Encyclopedia of RNA Fold-Small Molecule Interactions

2019-04-09

Abstract excerpt

Vascular Endothelial Growth Factor A (VEGFA) stimulates angiogenesis in human endothelial cells and increasing its expression is a potential treatment for heart failure, currently accomplished via gene or mRNA therapy. Herein, we describe a designed small molecule (TGP-377) that specifically and potently enhances VEGFA expression by targeting of a non-coding microRNA that regulates its expression. This investigat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 48579f4d-e000-5fdb-b215-6fb14e232a43
DOI: 10.26434/chemrxiv.7967291.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Design of a Small Molecule That Stimulates VEGFA Informed from an Expanded Encyclopedia of RNA Fold-Small Molecule InteractionsDOI 10.26434/chemrxiv.7967291.v1Read

Small molecules exploiting structural differences within microRNA-200 precursors family members reverse a type 2 diabetes phenotypeSemantic proximity Read

Physicochemical Principles Driving Small Molecule Binding to RNASemantic proximity Read

A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype.Semantic proximity Read

A chemoinformatics-guided platform for efficient discovery of RNA-binding small molecules: Proof-of-concept for myotonic dystrophy type 1Semantic proximity Read

RNA Therapeutics – The Next Generation of Drugs for Cardiovascular DiseasesSemantic proximity Read

Machine learning-guided design of artificial microRNAs for targeted gene silencingSemantic proximity Read

Accurately modelling RNase H-mediated antisense oligonucleotide efficacySemantic proximity Read

Development of a selection assay for small guide RNAs that drive efficient site-directed RNA editing.Semantic proximity Read

Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer TherapeuticsSemantic proximity Read

RNA therapeutics for cardiovascular diseaseSemantic proximity Read

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.Semantic proximity Read

To accelerate the Zika beat: Candidate design for RNA interference-based therapySemantic proximity Read