Article
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype.
Cell chemical biology - 17 Feb 2022
Haniff Hafeez S, Liu Xiaohui, Tong Yuquan, Meyer Samantha M, Knerr Laurent, Lemurell Malin, Abegg Daniel, Aikawa Haruo, Adibekian Alexander, Disney Matthew D
Abstract excerpt
MicroRNA families are ubiquitous in the human transcriptome, yet targeting of individual members is challenging because of sequence homology. Many secondary structures of the precursors to these miRNAs (pri- and pre-miRNAs), however, are quite different. Here, we demonstrate both in vitro and in cellulis that design of structure-specific small molecules can inhibit a particular miRNA family member to modulate a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.