Article

Small molecules exploiting structural differences within microRNA-200 precursors family members reverse a type 2 diabetes phenotype

2020-06-27

Abstract excerpt

MicroRNA families are pervasive in the human transcriptome, but specific targeting of individual members is a challenge because of sequence homology. Many of the secondary structures of the precursors to these miRs (pre-miRs), however, are quite different. Here, we demonstrate both in vitro and in cellulis that design of structure-specific small molecules can inhibit specific miR family members to modulate a dis...

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Literature Corpus work: ee38d725-f8e0-5daa-859a-b43142c9187e
DOI: 10.1101/2020.06.27.175281

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