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Article

A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 2002

Kao Richard Y T, Jenkins Jeremy L, Olson Karen A, Key Marc E, Fett James W, Shapiro Robert

Abstract excerpt

The results of previous preclinical and clinical studies have identified angiogenin (ANG) as a potentially important target for anticancer therapy. Here we report the design and implementation of a high-throughput screening assay to identify small molecules that bind to the ribonucleolytic active site of ANG, which is critically involved in the induction of angiogenesis by this protein. Screening of 18,310...

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Share to Anticarcinogenic Agents
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Nude

Share to Molecular Structure

Share to Neovascularization, Pathologic

Share to Ribonuclease, Pancreatic

Share to Structure-Activity Relationship

Share to Transplantation, Heterologous

Source

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Identifiers

PMID: 12118120
DOI: 10.1073/pnas.152342999
PMCID: PMC126625

Genes

ANG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity.PMID 12118120Read ↗

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