Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amino Acid Metabolism Subtypes in Neuroblastoma Identifying Distinct Prognosis and Therapeutic Vulnerabilities.

Journal of proteome research - 4 Apr 2025

Zhou Xing, Zhou Zhaokai, Qin Xiaohan, Cheng Jian, Fu Yongcheng, Wang Yuanyuan, Wang Jingyue, Qin Pan, Zhang Da

Abstract excerpt

Although amino acid (AA) metabolism is linked to tumor progression and could serve as an attractive intervention target, its association with neuroblastoma (NB) is unknown. Based on AA metabolism-related genes, we established three NB subtypes associated with distinct prognoses and specific functions, with C1 and C2 having better outcomes. The C1 displayed enhanced metabolic activity and recruited...

Topics

Join the communities discussing this publication.

Amino Acids
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Neuroblastoma
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Single-Cell Analysis

Tumor Microenvironment

Source

Identifiers

PMID: 39442086
DOI: 10.1021/acs.jproteome.4c00554

Genes

C3
C2
ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amino Acid Metabolism Subtypes in Neuroblastoma Identifying Distinct Prognosis and Therapeutic Vulnerabilities.PMID 39442086Read ↗

Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastomaSemantic proximity Read ↗

Amino acid metabolic reprogramming in the tumor microenvironment and its implication for cancer therapySemantic proximity Read ↗

Screening of targets related to amino acid metabolism in glioma to identify the tumor-promoting effects of its core gene ASLSemantic proximity Read ↗

Identification and Characterization of a Glucometabolic Prognostic Gene Signature in Neuroblastoma based on N6-methyladenosine Eraser ALKBH5Semantic proximity Read ↗

Metabolism of Amino Acids in CancerSemantic proximity Read ↗

Metabolic targeting of neuroblastoma, an updateSemantic proximity Read ↗

Joint metabolomics and transcriptomics analysis systematically reveal the impact of MYCN in neuroblastomaSemantic proximity Read ↗

Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinomaSemantic proximity Read ↗

Metabolism and Tumor Microenvironment-Associated Molecular Classification of NeuroblastomaSemantic proximity Read ↗

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastomaSemantic proximity Read ↗

A prognostic metabolism-related gene signature associated with the tumor immune microenvironment in neuroblastomaSemantic proximity Read ↗

Integration RNA bulk and single cell RNA sequencing to explore the change of BCAA metabolism-related immune microenvironment and construct prognostic signature in HNSCCSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.