Article

ALS mutations do not alter perineuronal net formation in human stem cell-derived motor neurons

2025-09-16

Abstract excerpt

<h4>Summary</h4> Perineuronal nets (PNNs) are extracellular matrix structures that stabilise synaptic inputs and regulate neuronal plasticity. Although PNN dysregulation is observed in several neurological disorders, their relevance to amyotrophic lateral sclerosis (ALS) remains unclear. In particular, the extent to which PNN alterations in ALS are motor neuron (MN)-intrinsic is unknown. We investigated whether h...

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Literature Corpus work: 4853f145-cbcf-541f-8fe8-3dc0625eb278
DOI: 10.1101/2025.09.13.676004

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