Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ALS mutations do not alter perineuronal net formation in human stem cell-derived motor neurons.

Communications biology - 19 May 2026

Kerins Caoimhe, Lieberam Ivo, Gentleman Eileen

Abstract excerpt

Perineuronal nets (PNNs) are extracellular matrix structures that stabilise synaptic inputs and play a role in regulating neuronal plasticity. Although PNN dysregulation is observed in several neurological disorders, their relevance to amyotrophic lateral sclerosis (ALS) remains unclear. In particular, the extent to which PNN alterations reported in ALS animal models are motor neuron (MN)-intrinsic is unknown. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Astrocytes
Share to Coculture Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Motor Neurons

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42156505
DOI: 10.1038/s42003-026-10244-6
PMCID: PMC13454605

Genes

PNN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALS mutations do not alter perineuronal net formation in human stem cell-derived motor neurons.PMID 42156505Read ↗

ALS mutations do not alter perineuronal net formation in human stem cell-derived motor neuronsSemantic proximity Read ↗

Characterization of Human iPSC-derived Spinal Motor Neurons by Single-cell RNA Sequencing.Semantic proximity Read ↗

Gene Expression Signatures of Sporadic ALS Motor Neuron PopulationsSemantic proximity Read ↗

Integrated profiling of iPSC-derived motor neurons carrying C9orf72, FUS, TARDBP, or SOD1 mutations.Semantic proximity Read ↗

Motor neurons from ALS patients with mutations in C9ORF72 and SOD1 exhibit distinct transcriptional landscapesSemantic proximity Read ↗

Characterization of human-iPSCs derived spinal motor neurons by single-cell RNA sequencingSemantic proximity Read ↗

Comparative Transcriptional Profiling of Motor Neuron Disorder-Associated Genes in Various Human Cell Culture ModelsSemantic proximity Read ↗

Transcriptomic profiling of symptomatic and end-stage SOD1-G93A transgenic mice reveals extracellular matrix components as key players in ALS pathogenesisSemantic proximity Read ↗

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS.Semantic proximity Read ↗

Sporadic ALS Astrocytes Induce Neuronal Degeneration In VivoSemantic proximity Read ↗

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor NeuronsSemantic proximity Read ↗

Proteomic signature and mesenchymal stromal/stem cell-derived extracellular vesicle treatment of iPSC motor neurons from different ALS patient groupsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.