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Article

Leukaemogenesis: more than mutant genes.

Nature reviews. Cancer - 1 Jan 2010

Chen Jianjun, Odenike Olatoyosi, Rowley Janet D

Abstract excerpt

Acute leukaemias are characterized by recurring chromosomal aberrations and gene mutations that are crucial to disease pathogenesis. It is now evident that epigenetic modifications, including DNA methylation and histone modifications, substantially contribute to the phenotype of leukaemia cells. An additional layer of epigenetic complexity is the pathogenetic role of microRNAs in leukaemias, and their key role in...

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Share to Acute Myeloid Leukemia Research
Share to Epigenesis, Genetic
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Histone Deacetylase Inhibitors Research

Share to Leukemia

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Identifiers

PMID: 20029422
DOI: 10.1038/nrc2765
PMCID: PMC2972637

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