Article

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

2022-10-24

Abstract excerpt

<h4>ABSTRACT</h4> The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs 1–3 , but also revealed how quickly viral escape can curtail effective options 4, 5 . With the emergence of the SARS-CoV-2 Omicron variant in late 2021, many clinically used antibody drug products lost potency, including Evusheld TM and its constituent, cilgavimab 4, 6 . Cilgavimab,...

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Literature Corpus work: 690fff28-c2dc-5327-999b-b77fe98cd1f8
DOI: 10.1101/2022.10.21.513237

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