Article

The absence of collagen VI reduces systolic function but paradoxically increases Ca <sup>2+</sup> release in the rat heart

2025-03-25

Abstract excerpt

Collagen VI has recently been strongly linked to poor outcomes in heart failure with preserved ejection fraction through increased endotrophin, a collagen VI-derived signalling molecule linked to fibrotic remodelling in cardiovascular disease. The mutation of collagen VI can result in Ullrich congenital muscular dystrophy and Bethlem myopathy, pointing to critical function in muscle physiology. However, the role o...

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Identifiers and source

Literature Corpus work: 4834454d-e1ea-5876-9e13-5f28fffb8511
DOI: 10.1101/2025.03.21.644665

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