Article

Collagen type VI regulates TGFβ bioavailability in skeletal muscle

2023-06-24

Abstract excerpt

Collagen VI-related disorders ( COL6 -RDs) are a group of rare muscular dystrophies caused by pathogenic variants in collagen VI genes ( COL6A1, COL6A2, and COL6A3 ). Collagen type VI is a heterotrimeric, microfibrillar component of the muscle extracellular matrix (ECM), predominantly secreted by resident fibroadipogenic precursor cells in skeletal muscle. The absence or mislocalizatoion of collagen VI in the E...

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Literature Corpus work: 477a953f-b270-5352-af46-fd37d7ab2add
DOI: 10.1101/2023.06.22.545964

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