Optimizing CRISPR/Cas9 System to Precisely Model Plasminogen Activator Inhibitor-1 Point Mutations in Mice

Abstract excerpt

CRISPR/Cas9 has become a powerful genome editing tool in recent years. CRISPR/Cas9 can be utilized to not only efficiently generate knock out models in various organisms, but also to precisely model human disease or variants to study gene function and develop therapies. However, the latter remains challenging because of low knock-in (KI) efficiency. In this study, precise gene editing modeling plasminogen activato...

Topics

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• Base Sequence
• CRISPR-Cas Systems
• Disease Models, Animal
• Hemophilia B
• Mice
• Mice, Inbred C57BL
• Molecular Sequence Data
• RNA, Guide, CRISPR-Cas Systems

Identifiers and source

Literature Corpus work

482cbd7d-0522-50e3-830d-5a58727fd21f

DOI

10.1101/254805