Article

Complexity of the eukaryotic dolichol-linked oligosaccharide scramblase suggested by activity correlation profiling mass spectrometry

2020-04-16

Abstract excerpt

The canonical pathway of N -linked protein glycosylation in yeast and humans involves transfer of the oligosaccharide moiety from the glycolipid Glc 3 Man 9 GlcNAc 2 -PP-dolichol to select asparagine residues in proteins that have been translocated into the lumen of the endoplasmic reticulum (ER). Synthesis of Glc 3 Man 9 GlcNAc 2 -PP-dolichol occurs in two stages, producing first the key intermediate Man...

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Literature Corpus work: 4827a805-da32-5ee3-bc51-290fe044ca78
DOI: 10.1101/2020.04.15.043679

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