Article
Oligosaccharyl transferase: gatekeeper to the secretory pathway.
Current opinion in chemical biology - 1 Dec 2002
Dempski Robert E, Imperiali Barbara
Abstract excerpt
Oligosaccharyl transferase is part of the macromolecular machinery that processes nascent proteins in the endoplasmic reticulum. The enzyme is highly conserved, catalyzes the initial step in the biosynthesis of N-linked glycoproteins and acts as a 'gatekeeper' for the secretory pathway. As more proteins associated with oligosaccharyl transferase are identified, the intricacies of the enzyme and the relationship...
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