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Article

Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1.

The Journal of biological chemistry - 12 Jul 2013

Jelk Jennifer, Gao Ningguo, Serricchio Mauro, Signorell Aita, Schmidt Remo S, Bangs James D, Acosta-Serrano Alvaro, Lehrman Mark A, Bütikofer Peter, Menon Anant K

Abstract excerpt

Mature dolichol-linked oligosaccharides (mDLOs) needed for eukaryotic protein N-glycosylation are synthesized by a multistep pathway in which the biosynthetic lipid intermediate Man5GlcNAc2-PP-dolichol (M5-DLO) flips from the cytoplasmic to the luminal face of the endoplasmic reticulum. The endoplasmic reticulum membrane protein Rft1 is intimately involved in mDLO biosynthesis. Yeast genetic analyses implicated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23720757
DOI: 10.1074/jbc.M113.479642
PMCID: PMC3711325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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