Article
Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 1996
Silberstein S, Gilmore R
Abstract excerpt
Asparagine-linked glycosylation is a highly conserved protein modification reaction that occurs in all eukaryotes. The initial stage in the biosynthesis of N-linked glycoproteins, catalyzed by the enzyme oligosaccharyltransferase (OST), involves the transfer of a preassembled high-mannose oligosaccharide from a dolichol-linked oligosaccharide donor onto asparagine acceptor sites in nascent proteins in the lumen...
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