Article
Convergent evolution in nucleocapsid facilitated SARS-CoV-2 adaptation for human infection.
Journal of virology - 22 Jul 2025
Lokugamage Kumari G, Zhou Yiyang, Alvarado R Elias, Plante Jessica A, Ahearn Yani, Chen Jennifer, Estes Leah, Meyers William, Nilsson Jakob, Routh Andrew L, Walker David H, Menachery Vineet D, Johnson Bryan A
Abstract excerpt
During the early stages of the COVID-19 pandemic, several SARS-CoV-2 variants of concern (VOCs) independently acquired mutations in the highly variable 203-205 amino acid region of the nucleocapsid (N) protein including R203K + G204R (found in the Alpha, Gamma, and Omicron variants), R203M (in Delta), and T205I (in Beta). In previous research, we demonstrated that the R203K + G204R mutation significantly enhances...
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