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Article

Modulation of biophysical properties of nucleocapsid protein in the mutant spectrum of SARS-CoV-2.

eLife - 28 Jun 2024

Nguyen Ai, Zhao Huaying, Myagmarsuren Dulguun, Srinivasan Sanjana, Wu Di, Chen Jiji, Piszczek Grzegorz, Schuck Peter

Abstract excerpt

Genetic diversity is a hallmark of RNA viruses and the basis for their evolutionary success. Taking advantage of the uniquely large genomic database of SARS-CoV-2, we examine the impact of mutations across the spectrum of viable amino acid sequences on the biophysical phenotypes of the highly expressed and multifunctional nucleocapsid protein. We find variation in the physicochemical parameters of its extended...

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Identifiers

PMID: 38941236
DOI: 10.7554/eLife.94836
PMCID: PMC11213569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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