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Article

Analysis of SARS-CoV-2 nucleocapsid phosphoprotein N variations in the binding site to human 14-3-3 proteins.

Biochemical and biophysical research communications - 10 Sept 2021

Del Veliz Samanta, Rivera Lautaro, Bustos Diego M, Uhart Marina

Abstract excerpt

The SARS-CoV-2 N protein binds several cell host proteins including 14-3-3γ, a well-characterized regulatory protein. However, the biological function of this interaction is not completely understood. We analyzed the variability of ∼90 000 sequences of the SARS-CoV-2 N protein, particularly, its mutations in disordered regions containing binding motifs for 14-3-3 proteins. We studied how these mutations affect...

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Identifiers

PMID: 34246830
DOI: 10.1016/j.bbrc.2021.06.100
PMCID: PMC8249750

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