Article

Mechanism of SARS-CoV-2 Nucleocapsid Protein Phosphorylation-induced Functional Switch

2025-09-12

Abstract excerpt

<h4>ABSTRACT</h4> The SARS-CoV-2 nucleocapsid protein (Np) is essential for viral RNA replication and genomic RNA packaging. Phosphorylation of Np within its central Ser-Arg-rich (SRR) linker is proposed to modulate these functions. To gain mechanistic insights into these distinct roles, we performed in vitro biophysical and biochemical studies using recombinantly expressed ancestral Np and phosphomimetic SRR var...

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Literature Corpus work: 6ce10131-511f-5e34-a25a-18d793d26a3e
DOI: 10.1101/2025.09.12.675721

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