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Article

Human 14-3-3 Proteins Site-selectively Bind the Mutational Hotspot Region of SARS-CoV-2 Nucleoprotein Modulating its Phosphoregulation.

Journal of molecular biology - 30 Jan 2023

Tugaeva Kristina V, Sysoev Andrey A, Kapitonova Anna A, Smith Jake L R, Zhu Phillip, Cooley Richard B, Antson Alfred A, Sluchanko Nikolai N

Abstract excerpt

Phosphorylation of SARS-CoV-2 nucleoprotein recruits human cytosolic 14-3-3 proteins playing a well-recognized role in replication of many viruses. Here we use genetic code expansion to demonstrate that 14-3-3 binding is triggered by phosphorylation of SARS-CoV-2 nucleoprotein at either of two pseudo-repeats centered at Ser197 and Thr205. According to fluorescence anisotropy measurements, the...

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Identifiers

PMID: 36427566
DOI: 10.1016/j.jmb.2022.167891
PMCID: PMC9683861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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