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Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and primary sensory neuron Ca 2+ activity in chemotherapy-induced peripheral neuropathy

2021-05-23

Abstract excerpt

Chemotherapy-induced peripheral neuropathy (CIPN) affects about 68% of patients undergoing chemotherapy and causes severe neuropathic pain which is debilitating health problem and greatly reduces quality of life. Cisplatin is a commonly used platinum-based chemotherapeutic drug known to cause CIPN, possibly by causing oxidative stress damage to primary sensory neurons. Metabotropic glutamate receptors (mGluRs) are...

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Literature Corpus work: 480c1e03-b174-5dae-82c0-cccf4ae942af
DOI: 10.1101/2021.05.21.445188

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Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and primary sensory neuron Ca 2+ activity in chemotherapy-induced peripheral neuropathyDOI 10.1101/2021.05.21.445188Read

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Meclizine and metabotropic glutamate receptor agonists attenuate severe pain and primary sensory neuron Ca <sup>2+</sup> activity in chemotherapy-induced peripheral neuropathy

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