Article

Inhibition of muscarinic receptor signaling protects human enteric inhibitory neurons against platin chemotherapy toxicity

2023-03-10

Abstract excerpt

GI toxicity is a common dose-limiting adverse effect of platin chemotherapy treatment. Up to 50% of cancer survivors continue to experience symptoms of chronic constipation or diarrhea induced by their chemotherapy for many years after their treatment. This drug toxicity is largely attributed to damage to enteric neurons that innervate the GI tract and control GI motility. The mechanisms responsible for platin-ind...

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Identifiers and source

Literature Corpus work: 69067edc-dbcc-503c-9fce-48d60d743d37
DOI: 10.1101/2023.03.08.531806

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