Article

Central norepinephrine transmission is required for stress-induced repetitive behavior in two rodent models of obsessive-compulsive disorder

2019-11-25

Abstract excerpt

<h4>Rationale</h4> Obsessive-compulsive disorder (OCD) is characterized by repetitive behaviors exacerbated by stress. Many OCD patients do not respond to available pharmacotherapies, but neurosurgical ablation of the anterior cingulate cortex (ACC) can provide symptomatic relief. Although the ACC receives noradrenergic innervation and expresses adrenergic receptors (ARs), the involvement of norepinephrine (NE) i...

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Literature Corpus work: 47fbc352-1a8c-5239-a5ef-1527d637d929
DOI: 10.1101/855205

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