Article
Distinct behavioral traits and associated brain regions in mouse models for obsessive-compulsive disorder.
Behavioral and brain functions : BBF - 18 May 2021
Chen Xiao, Yue Jihui, Luo Yuchong, Huang Lianyan, Li Boxing, Wen Shenglin
Abstract excerpt
BACKGROUND: Obsessive-compulsive disorder (OCD) is a mental disease with heterogeneous behavioral phenotypes, including repetitive behaviors, anxiety, and impairments in cognitive functions. The brain regions related to the behavioral heterogeneity, however, are unknown. METHODS: We systematically examined the behavioral phenotypes of three OCD mouse models induced by pharmacological reagents [RU24969,...
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