Article

The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by which LA1011 may Improve the Prognosis of Alzheimer’s Disease

2023-04-27

Abstract excerpt

Chaperone systems play a major role in the decline of cognition and contribute to neurological pathologies such as Alzheimer’s disease (AD). While such a decline may occur naturally with age or with stress or trauma, the mechanisms involved have remained elusive. The current models suggest that amyloid-β (Aβ) plaque formation leads to the hyperphosphorylation of tau by a Hsp90 dependent process that triggers tau n...

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Literature Corpus work: 47f1744d-e87d-5587-8b65-78f96fa767fb
DOI: 10.1101/2023.04.27.538547

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