Article
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Mar 2008
Wang Lizhen, Xie Chengsong, Greggio Elisa, Parisiadou Loukia, Shim Hoon, Sun Lixin, Chandran Jayanth, Lin Xian, Lai Chen, Yang Wan-Jou, Moore Darren J, Dawson Ted M, Dawson Valina L, Chiosis Gabriela, Cookson Mark R, Cai Huaibin
Abstract excerpt
Parkinson's disease (PD), a progressive neurodegenerative disease characterized by bradykinesia, rigidity, and resting tremor, is the most common neurodegenerative movement disorder. Although the majority of PD cases are sporadic, some are inherited, including those caused by leucine-rich repeat kinase 2 (LRRK2) mutations. The substitution of serine for glycine at position 2019 (G2019S) in the kinase domain of...
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