Article

Apolipoprotein E2 Promotes Melanoma Growth, Metastasis, and Protein Synthesis via the LRP1 Receptor

2022-10-05

Abstract excerpt

The secreted lipid transporter apolipoprotein E (APOE) plays important roles in atherosclerosis and Alzheimer’s disease and has been implicated as a suppressor of melanoma progression. APOE germline genotype predicts human melanoma outcomes, as APOE4 and APOE2 allele carriers exhibit increased versus reduced melanoma survival, respectively, relative to APOE3 homozygotes. While the APOE4 variant was recently sh...

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Literature Corpus work: 47ee623a-884c-5897-b82b-aa0d6a8b3219
DOI: 10.1101/2022.10.03.510632

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