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Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis

19 Jun 2023

Abstract excerpt

The secreted lipid transporter apolipoprotein E (APOE) plays important roles in atherosclerosis and Alzheimer's disease and has been implicated as a suppressor of melanoma progression. The APOE germline genotype predicts human melanoma outcomes, with APOE4 and APOE2 allele carriers exhibiting prolonged and reduced survival, respectively, relative to APOE3 homozygotes. While the APOE4 variant was recently shown to...

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PMID: 37335131
DOI: 10.1158/0008-5472.can-23-1252

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