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Article

Germline genetic determination of cancer progression and survival

2019-03-13

Abstract excerpt

We report the surprising finding that common germline polymorphisms of APOE , present in approximately 39% of Caucasians, predict survival outcomes in human melanoma. Analysis of The Cancer Genome Atlas revealed that carriers of the APOE2 variant experienced shorter survival relative to APOE3 homozygotes, while APOE4 variant carriers exhibited increased survival. Consistent with this, melanoma growth in human...

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Identifiers and source

Literature Corpus work
308ca8bb-320e-57fb-add2-0ab6b36f8ab0
DOI
10.1101/576181
Open publication

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Germline genetic determination of cancer progression and survivalDOI 10.1101/576181
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