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The RPL/RPS Gene Signature of Melanoma CTCs Associates with Brain Metastasis

2 Nov 2022

Abstract excerpt

Melanoma brain metastasis (MBM) is linked to poor prognosis and low overall survival. We hypothesized that melanoma circulating tumor cells (CTC) possess a gene signature significantly expressed and associated with MBM. Employing a multipronged approach, we provide first-time evidence identifying a common CTC gene signature for ribosomal protein large/small subunits (RPL/RPS) which associate with MBM onset and...

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PMID: 36407834
DOI: 10.1158/2767-9764.crc-22-0337

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