Article

TP53 mutation at codon 179 metabolically reprograms cancer cells to promote invasion

2025-01-07

Abstract excerpt

<title>Abstract</title> <p>Mutations in the tumor suppressor, <italic>TP53</italic>, are prevalent in human cancers; yet their functional implications remain unclear. Through comprehensive pan-cancer database analysis, we identified H179 mutations in <italic>TP53</italic> as significantly associated with poor disease-free survival across multiple cancer types. Functional studies in lung, ovarian, and prostate can...

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Literature Corpus work: 21994b2d-2bb2-5c30-891b-b79d0587565c
DOI: 10.21203/rs.3.rs-5524623/v1

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