Article
Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins.
Cancer discovery - 1 Aug 2018
Zhang Maomao, Di Martino Julie S, Bowman Robert L, Campbell Nathaniel R, Baksh Sanjeethan C, Simon-Vermot Theresa, Kim Isabella S, Haldeman Pearce, Mondal Chandrani, Yong-Gonzales Vladimir, Abu-Akeel Mohsen, Merghoub Taha, Jones Drew R, Zhu Xiphias Ge, Arora Arshi, Ariyan Charlotte E, Birsoy Kivanç, Wolchok Jedd D, Panageas Katherine S, Hollmann Travis, Bravo-Cordero Jose Javier, White Richard M
Abstract excerpt
Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the mechanisms by which adipocytes influence melanoma are poorly understood. Using in vitro and in vivo models, we find that adipocytes increase proliferation and invasion of adjacent melanoma cells. Additionally, adipocytes directly transfer lipids...
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