Article

Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification

2026-03-02

Abstract excerpt

<h4>ABSTRACT</h4> The pathologic, osteogenic differentiation of fibroadipogenic progenitor cells (FAPs) is the primary recognized contributor to ectopic bone formation in fibrodysplasia ossificans progressiva (FOP) and trauma-induced heterotopic ossification (HO). Both conditions are characterized by up-regulated BMP signaling – the former by a gene mutation rendering the BMP receptor ACVR1 susceptible to activat...

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Literature Corpus work: 47e3ffd9-81a3-5a23-b103-f83ace4676d4
DOI: 10.64898/2026.02.26.708276

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