Article

Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressiva

2025-01-21

Abstract excerpt

<h4>Background</h4> Fibrodysplasia ossificans progressiva (FOP) is caused by an activating mutation (p.R206H) in the type I BMP receptor ALK2, leading to heterotopic ossification (HO) in soft connective tissues. While aberrant Activin A-induced SMAD signaling is central in FOP pathogenesis, global signaling alterations remain poorly understood. <h4>Methods</h4> We performed phosphoproteomics, transcriptomics and...

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Literature Corpus work: f11bb8e5-47a5-5de6-8b90-9deb9d34cb9f
DOI: 10.1101/2025.01.21.634061

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Multi-omics reveals global signaling rewiring and identifies Activin A-induced dysregulation of FOS/Activator Protein 1 as a novel target in Fibrodysplasia ossificans progressivaDOI 10.1101/2025.01.21.634061Read

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