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Article

Fibrodysplasia ossificans progressiva.

Best practice & research. Clinical rheumatology - 1 Mar 2008

Kaplan Frederick S, Le Merrer Martine, Glaser David L, Pignolo Robert J, Goldsby Robert E, Kitterman Joseph A, Groppe Jay, Shore Eileen M

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP), a rare and disabling genetic condition of congenital skeletal malformations and progressive heterotopic ossification (HO), is the most catastrophic disorder of HO in humans. Episodic disease flare-ups are precipitated by soft tissue injury, and immobility is cumulative. Recently, a recurrent mutation in activin receptor IA/activin-like kinase 2 (ACVR1/ALK2), a bone...

Topics

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Activin Receptors, Type I
Bone Morphogenetic Protein Receptors, Type I
Bone Morphogenetic Proteins
Disease Models, Animal
Myositis Ossificans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ossification, Heterotopic

Source

Open in PubMed Open full text

Identifiers

PMID: 18328989
DOI: 10.1016/j.berh.2007.11.007
PMCID: PMC2424023

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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