Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification.

doi:10.1016/j.ymthe.2017.01.008

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Article

Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification.

Molecular therapy : the journal of the American Society of Gene Therapy - 2 Aug 2017

Agarwal Shailesh, Loder Shawn J, Breuler Christopher, Li John, Cholok David, Brownley Cameron, Peterson Jonathan, Hsieh Hsiao H, Drake James, Ranganathan Kavitha, Niknafs Yashar S, Xiao Wenzhong, Li Shuli, Kumar Ravindra, Tompkins Ronald, Longaker Michael T, Davis Thomas A, Yu Paul B, Mishina Yuji, Levi Benjamin

Abstract excerpt

Trauma-induced heterotopic ossification (tHO) is a condition of pathologic wound healing, defined by the progressive formation of ectopic bone in soft tissue following severe burns or trauma. Because previous studies have shown that genetic variants of HO, such as fibrodysplasia ossificans progressiva (FOP), are caused by hyperactivating mutations of the type I bone morphogenetic protein receptor (T1-BMPR)...

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PMID: 28716575
DOI: 10.1016/j.ymthe.2017.01.008
PMCID: PMC5542633

Genes

ACVR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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