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From mysteries to medicines: drug development for fibrodysplasia ossificans progressiva

25 Jul 2013

Abstract excerpt

INTRODUCTION: Fibrodysplasia ossificans progressiva (FOP) is the most disabling disorder of skeletal metamorphosis in humans and leads to the formation of a second skeleton of heterotopic bone. Presently, there is no effective treatment. AREAS COVERED: In this review, the authors discuss heterozygous activating mutations in Activin receptor A, type I/ Activin-like kinase 2 (ACVR1/ALK2), a bone morphogenetic...

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PMID: 24800180
DOI: 10.1517/21678707.2013.825208

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