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Uremic plasma proteins accumulate in peripheral blood mononuclear leukocytes inducing apoptosis: insights in the immuno-proteostasis response of chronic kidney disease.

2023-01-09

Abstract excerpt

Peripheral blood mononuclear leukocytes (PBL) of uremic patients (u-PBL) prematurely die by apoptosis, thus sustaining leukopenia and immune dysfunction. Uremic retention solutes have been alleged to playing a causal role in this immune cell defect. However, both the molecular identity and pro-apoptotic mechanism of these solutes remain poorly characterized. In this study, we prepared a fraction of the uremic plas...

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Literature Corpus work
47d6e040-7e11-5434-a576-6bba5dbfc3ff
DOI
10.21203/rs.3.rs-2429421/v1
Open publication

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Uremic plasma proteins accumulate in peripheral blood mononuclear leukocytes inducing apoptosis: insights in the immuno-proteostasis response of chronic kidney disease.DOI 10.21203/rs.3.rs-2429421/v1
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