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Normothermic human kidney preservation drives iron accumulation and ferroptosis

1 Jul 2025

Abstract excerpt

Ex vivo normothermic machine perfusion has been proposed to protect deceased donor kidneys. However, its benefits remain ambiguous. We postulate that the use of red blood cells (RBCs) and associated secondary hemolysis may in fact cause renal injury, offsetting potential advantages. During 48-hour normothermic perfusion of seven human donor kidneys, we observed progressive hemolysis, leading to iron accumulation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40595589
DOI: 10.1038/s41467-025-61058-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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