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GFR is a Key Determinant of Red Blood Cell Survival in Anemia Associated With Progressive CKD

21 Dec 2024

Abstract excerpt

Introduction Anemia is a common and clinically significant complication observed in patients with chronic kidney disease (CKD), resulting from complex interactions between renal dysfunction, erythropoietin (EPO) deficiency, and altered iron metabolism. In murine CKD models, red blood cell (RBC) death or eryptosis, characterized by exposure of phosphatidylserine (PS) on the outer membrane of RBCs, was observed to...

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PMID: 40225399
DOI: 10.1016/j.ekir.2024.12.023

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