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Article

The power of five - inositol polyphosphate 5-phosphatase gene mutations at the intersection of development and disease.

FEBS letters - 1 Sept 2026

McGrath Meagan J, Davies Elizabeth M, Ooms Lisa M, Nanayakkara Randini, Gurung Rajendra, Jones Emily I, Mitchell Christina A

Abstract excerpt

Phosphoinositides are transient signaling lipids, derived from the reversible phosphorylation of phosphatidylinositol on intracellular membranes, which serve as master regulators of many essential cellular functions. Seven distinct phosphoinositide species require precise spatiotemporal control, which is regulated by specific phosphatidylinositol kinases and phosphatases. Here, we review one such family, the...

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Topics

Phosphoric Monoester Hydrolases
Animals
Humans
Mutation
Inositol Polyphosphate 5-Phosphatases

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Identifiers

PMID: 41406168
DOI: 10.1002/1873-3468.70247
PMCID: PMC13573098

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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