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Article

PTEN regulates retinal interneuron morphogenesis and synaptic layer formation.

Molecular and cellular neurosciences - 1 Feb 2012

Sakagami Kiyo, Chen Bryan, Nusinowitz Steven, Wu Hong, Yang Xian-Jie

Abstract excerpt

The lipid phosphatase PTEN is a critical negative regulator of extracellular signal-induced PI3K activities, yet the roles of PTEN in the neural retina remain poorly understood. Here, we investigate the function of PTEN during retinal development. Deletion of Pten at the onset of neurogenesis in retinal progenitors results in the reduction of retinal ganglion cells and rod photoreceptors, but increased Müller...

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Source

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Identifiers

PMID: 22155156
DOI: 10.1016/j.mcn.2011.11.007
PMCID: PMC3278565

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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