Article
Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high-frequency hearing acquisition.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2012
Rodriguez Laura, Simeonato Elena, Scimemi Pietro, Anselmi Fabio, Calì Bianca, Crispino Giulia, Ciubotaru Catalin D, Bortolozzi Mario, Ramirez Fabian Galindo, Majumder Paromita, Arslan Edoardo, De Camilli Pietro, Pozzan Tullio, Mammano Fabio
Abstract excerpt
Phosphatidylinositol phosphate kinase type 1γ (PIPKIγ) is a key enzyme in the generation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] and is expressed at high levels in the nervous system. Homozygous knockout mice lacking this enzyme die postnatally within 24 h, whereas PIPKIγ(+/-) siblings breed normally and have no reported phenotype. Here we show that adult PIPKIγ(+/-) mice have dramatically elevated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.