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Genetic Control of MAP3K1 in Eye Development and Sex Differentiation

23 Dec 2021

Abstract excerpt

The MAP3K1 is responsible for transmitting signals to activate specific MAP2K-MAPK cascades. Following the initial biochemical characterization, genetic mouse models have taken center stage to elucidate how MAP3K1 regulates biological functions. To that end, mice were generated with the ablation of the entire Map3k1 gene, the kinase domain coding sequences, or ubiquitin ligase domain mutations. Analyses of the...

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PMID: 35011600
DOI: 10.3390/cells11010034

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