Article

Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain

2020-01-30

Abstract excerpt

Phosphatidylinositol-4,5-bisphosphate (PI-4,5-P 2 ) is critical for synaptic vesicle docking and fusion and generation of the second messengers, diacylglycerol and inositol-1,4,5-trisphosphate. PI-4,5-P 2 can be generated by two families of kinases: type 1 phosphatidylinositol-4-phosphate 5-kinases, encoded by PIP5K1A, PIP5K1B and PIP5K1C, and type 2 phosphatidylinositol-5-phosphate 4-kinases, encoded by PIP4K2A...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 45b7346b-37a2-51b0-89be-06dc4c0c06e5
DOI: 10.1101/2020.01.29.925685

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brainDOI 10.1101/2020.01.29.925685Read

Differential and compensatory roles for type I phosphatidylinositol-4-phosphate-5-kinase isoforms in retinal function and healthSemantic proximity Read

Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.Semantic proximity Read

Limb-clasping, cognitive deficit and increased vulnerability to kainic acid-induced seizures in neuronal glycosylphosphatidylinositol deficiency mouse models.Semantic proximity Read

Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment.Semantic proximity Read

Protective role of the lipid phosphatase Fig4 in the adult nervous system.Semantic proximity Read

PIPs in neurological diseases.Semantic proximity Read

Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.Semantic proximity Read

Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II.Semantic proximity Read

The roles of diacylglycerol kinases in the central nervous system: review of genetic studies in mice.Semantic proximity Read

Genetic Dissection of the role of <i>Piga</i> and <i>Pgap2</i> in the embryonic mouse brainSemantic proximity Read

Limb-clasping, cognitive deficit and increased vulnerability to kainic acid - induced seizures in neuronal GPI anchor deficiency mouse modelsSemantic proximity Read

Multi-omics analyses reveal novel effects of PLCγ2 deficiency in the mouse brainSemantic proximity Read